i hear ya on the E. i've never had a bad experience though. then again, i have really high serotonin levels to begin with. but if you think about it... if it didn't cause all that damage to your spinal cord, wouldn't it, in moderation and if regulated properly so you got the pure stuff, be the perfect "cure" for depression?

only then you'd have to make sure you experienced the downsides of life too. it's the opposite of the zombie effect, in a way.